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Genetic Insights
Genetic Insights
You deserve to know as much as you can to help prevent future health problems. Genetic Insights is a health screening offering that helps you to identify health risks based on your genetics. Read moreTest details
Sample type:
Saliva Sample
Preparation:
You don’t need to do anything special to prepare for your test.
All you need to do is follow the detailed instructions inside the home collection kit on how to collect your small saliva sample.
$199.00
+ $12.00 Physician Service Fee
Who
This test is for anyone 18+ who wants to better understand and stay ahead of certain genetic health risks.
Purchases not currently available in: AK, AZ, HI, and NY.
How
You’ll receive a kit to collect a saliva sample at home. The kit includes a prepaid FedEx mailer bag to send your saliva sample back to a Quest lab.
Note: Saliva-based DNA tests are just as accurate as blood-based DNA tests.
How
Saliva Sample
What's tested?
This test uses advanced next-generation sequencing technology to look for thousands of DNA variants in 36 genes that are linked to 23 health conditions.
| Health concern | Condition name | Gene(s) tested |
|---|---|---|
| Breast cancer | ATM-associated cancer Hereditary breast and ovarian cancer PALB2-associated cancer |
ATM BRCA1, BRCA2 PALB2 |
| Colon cancer | APC-associated cancer BMPR1A-associated juvenile polyposis syndrome Lynch syndrome MUTYH-associated polyposis POLD1/POLE-associated cancer SMAD4-associated juvenile polyposis syndrome/HHT |
APC BMPR1A MLH1, MSH2, MSH6, PMS2 MUTYH POLD1, POLE SMAD4 |
| Breast and colon cancer | CHEK2-associated cancer Peutz-Jeghers syndrome |
CHEK2 STK11 |
| Heart and blood health | Cardiomyopathy (heart disease) Familial hypercholesterolemia (very high cholesterol) Hereditary hemochromatosis (iron overload) Hereditary thrombophilia (blood clots) |
MYBPC3, MYH7 APOB, LDLR, PCSK9 HFE* F2*, F5* |
| Connective tissue disorders | Classical Ehlers-Danlos syndrome Familial thoracic aortic aneurysm and dissection Loeys-Dietz syndrome Marfan syndrome Vascular Ehlers-Danlos syndrome |
COL5A1, COL5A2 ACTA2 TGFBR1, TGFBR2, TGFB2, TGFB3 FBN1 COL3A1 |
| Carrier status | Cystic fibrosis Sickle cell anemia Tay-Sachs disease |
CFTR HBB* HEXA |
*Only select DNA variant(s) are reported.
FAQs
Your results will tell you if you have a higher than typical chance of developing certain health conditions, based on your DNA. Genetic Insights provides easy-to-understand genetic health reports with next steps to empower you and your family to determine the healthiest path forward.
This test is a genetic screening test. It looks for variants in your DNA that can put you at higher risk for certain health problems.
It’s different than a diagnostic test, which tells you that you definitely have a certain health problem.
Genetic Insights can’t tell you if you do or do not have a certain health problem (like cancer or a heart condition). But your results can provide valuable information to help you take steps that may pave the way to a healthier future.
If your screening test shows that you have a DNA variant, it’s important to talk with your doctor.
We know you’re concerned about the privacy of your test results. And Genetic Insights is designed to protect the security and confidentiality of your test results.
Quest Diagnostics performs your test and gives you the results on a secure portal. And like most healthcare companies, doctors, and other healthcare providers, Quest Diagnostics is required to follow the federal law called the Health Insurance Portability and Accountability Act (HIPAA).
What does that mean?
Quest Diagnostics will share your test results with the PWNHealth doctors and genetic counselors involved in your test—but isn’t allowed to share results in any ways that are not covered by the HIPAA privacy practices. You can find a list of these in the Quest Diagnostics detailed Notice of Privacy Practices. For example, Quest Diagnostics will never share your results with your insurance company, unless you give your permission, or the law requires it.
Yes. While it may be hard to believe, saliva-based DNA tests are just as accurate as blood-based DNA tests. That’s because your DNA is the same whether it's in your saliva or your blood.
No. The sample tube used to collect your saliva contains a stabilizing solution. This solution protects the quality of your saliva for several months, in both hot and cold temperatures.
Next-generation sequencing (NGS) technology can analyze millions of segments in your DNA, including thousands of locations within each of your genes. It looks at significantly more places than the standard microarray technology used by some other at-home genetic tests. A more thorough look at your genes means a higher chance of detecting something you should know about.
Here are some possible considerations:
- Genetic test results affect you and your family members. You share your genes with your family. If a DNA variant is found, it’s important to discuss your results with family members so they can talk to their doctor to see if genetic testing is right for them.
- You may learn something that you’re not expecting. It’s best to review all the health conditions that Genetic Insights tests for so you’re better prepared for all the possible results.
- After you receive your results, you cannot unlearn the information. It’s important not to assume that learning information about your genetics is always good news or information you’d welcome.
- Getting genetic testing could affect your ability to purchase life, disability, or long-term care insurance. The Genetic Nondiscrimination Act (GINA) makes it illegal for health insurance companies or employers to discriminate against you based on your genetic data. (There are a few exceptions for military members and small employers.) But GINA does not cover other types of insurance including life, disability, or long-term care insurance.
Yes! Stay tuned for additional Genetic Insights health tests in the coming months.