Name: Sickle Cell Trait Screen Test with Reflex
Brand: Quest
SKU: 37679M
Price: 60 USD
Availability: InStock

Sickle Cell Trait Screen Test with Reflex

This sickle cell trait test is a solubility test which detects abnormal types of hemoglobin associated with various disorders such as sickle cell anemia, a blood disorder caused by a genetic mutation. If your sickle cell screening is abnormal, additional tests are performed to determine which type of abnormal hemoglobin is present. Read more

Test details

Sample type:

Blood

Preparation:

You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.

Test type: In Person

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$60.00

+ $6.00 Physician Service Fee

Quantity

Do you have any of the following severe symptoms associated with Sickle Cell Anemia?

Known anemia

Frequent infection

Extreme pain

Swelling of the hands and feet

Delayed growth/puberty

I don't have any of these severe symptoms associated with Sickle Cell Anemia

What

A screen for the presence of abnormal types of hemoglobin, and if positive, a reflex test for the presence of sickle hemoglobin proteins (hemoglobin S and Hemoglobin C-Harlem).

Who

Must be 18+ years of age to purchase.

How

Blood

Where

Find a location near you

Schedule an appointment, then visit a Quest Diagnostics patient service center location.

About the Test

This sickle cell screening test detects Hemoglobin S and Hemoglobin C-Harlem, which are abnormal types of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen throughout the body. These solubility tests are used by physicians to help diagnose sickle cell anemia; a genetic blood disorder caused by a gene mutation. Red blood cells are usually round and flexible and can move easily through blood vessels. 

This test can be used by student athletes to fulfill their NCAA requirement to provide their school with documented results of a sickle cell solubility test. This requirement provides documented results for coaches and athletic trainers to understand if athletes may need to take precautions.¹

With Quest, you can buy a sickle cell test online and get testing at a nearby location – no doctor’s visit required.

This test may be right for you if:

You are of African, Mediterranean, Middle Eastern, Indian, South American, or Caribbean descent
You have one or both parents with either sickle cell disease or sickle cell trait
You have other family members with Sickle cell disease or sickle cell trait

Measures the following components:

Sickle Cell Trait Screen - The sickle cell solubility test is a qualitative test based on the relative insolubility of sickling hemoglobins compared to other hemoglobin variants. A positive test indicates the presence of a sickling hemoglobin.

Hemoglobinopathy (Hb) Evaluation - several tests are available for evaluating the type and relative amount of both normal and abnormal hemoglobin cells. These methods separate the different types of hemoglobin that are present so that they can be identified and measured. They may be used for screening, diagnosis and/or monitoring sickle cell disease or sickle cell trait. Hemoglobinopathy evaluation testing includes:

Hemoglobin electrophoresis
Hemoglobin fractionation by HPLC
Isoelectric focusing
Mass spectrometry
Capillary zone

There's no cure for most people with sickle cell anemia. Treatments can relieve pain and help prevent complications associated with the disease.

Signs and symptoms of sickle cell anemia usually appear around 6 months of age. They vary from person to person and may change over time.

Signs and symptoms can include:

Sickled cells break apart easily and die more quickly than normal cells. Red blood cells usually live for about 120 days before they need to be replaced. But sickle cells typically die in 10 to 20 days, leaving a shortage of red blood cells (anemia). Without enough red blood cells, the body can't get enough oxygen, causing fatigue.

Red blood cells travel through the small blood vessels in the body. Sickle-shaped cells can get stuck, causing episodes of severe pain, also called pain crises. The pain from blocked cells can vary in intensity and may last from hours up to several days. Extreme crises may require emergency medical attention. Some people with sickle cell anemia may only have a couple of pain crises per year while others may be more frequent and can turn into chronic pain from damage to the bones or joints.

The spleen is an organ that helps fight infection and gets damaged by the blockage of sickle cells. Without the spleen functioning properly, it increases the chance for infections that can be life-threatening, like pneumonia. Vaccinations and antibiotics can help protect children with sickle-cell anemia from getting dangerous infections.

The sickle-shaped red blood cells can block blood circulation to the hands and feet, causing swelling and fever and is often the first symptom in infants and children.

Sickle-shaped blood cells can block the tiny blood vessels in the eye, damaging the retina, which is the part of the eye that processes visual images, causing retinopathy, blockage and thinning of the retina and choroid.

Red blood cells carry oxygen and nutrients to the body. Because they have a shorter life span than healthy red blood cells, it causes a shortage of red blood cells which can slow growth in infants and children and cause a delay in puberty.

You must be 18 years of age or older to purchase a test on questhealth.com. This test requires specimen collection at a Quest Diagnostics location or through Quest Mobile™, a convenient option for in-home sample collection*. Collection not available in AK, AZ, or HI.

*Check your zip code here for service availability, not available in all locations.

You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.

After you provide your specimen, it generally takes up to 5 business days to process and release your test results. However, processing times may vary. Your test results will be available in a clear and easy-to-read report. If your results differ from expected ranges, you may receive an alert call from an independent healthcare coordinator. Independent physicians are available to discuss questions or concerns you may have regarding your results. This physician may be able to prescribe medication, if appropriate.

If your sickle cell trait screen results are positive, the lab will perform an additional test (hemoglobinopathy evaluation) on the sample you have already provided at no extra cost to you. This additional testing can provide additional diagnostic information to help with care.

How it works

questhealth.com offers 100+ consumer-initiated Quest Diagnostics lab tests to empower you to have more control over your health journey. Choose from a variety of test types that best suit your needs.

In-person
In-home sample collection

Buy a lab test

No doctor visit is required for purchase.

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Register your test
& schedule an appointment

Book a visit to one of 2000+ Quest locations.

Visit Quest for sample collection

Complete your test sample collection during your scheduled appointment.

Get fast results

Access results online as soon as they’re available. You will be emailed when they are ready. Discuss your results with an independent physician at no extra cost. Treatment options may be available.

Buy a lab test
+ in-home sample collection

No doctor visit required for purchase. If in-home service is available in your area, purchase for an additional $79 fee.

Buy now

Register your test
& schedule an appointment

After you make a purchase, register your test and Quest Mobile will contact you to schedule an in-home sample collection appointment.

In-home sample collection

A Quest Mobile phlebotomist will collect your sample and deliver it to Quest Diagnostics.

Get fast results

Access results online as soon as they’re available. You will be emailed when they are ready. Discuss your results with an independent physician at no extra cost. Treatment options may be available.

FAQs

Is Sickle Cell Trait the same as Sickle Cell Disease?

People with sickle cell disease have the hemoglobin S gene mutation on both of their beta globin genes, whereas people with sickle cell trait (Hgb A/S) have the mutation on only one beta globin gene.

People with sickle cell trait are carriers of the mutation and are generally asymptomatic, however, there are rare cases where sickle cell formation can lead to pain crises in some people from certain conditions including high altitudes, dehydration, increased air pressure. Athletes and those who participate in activities like flying or scuba diving may be more vulnerable to complications of sickle cell trait.

Is Sickle Cell Anemia the same as Sickle Cell Disease?

Sickle cell disease refers to the group of genetic sickling disorders while sickle cell anemia is the most severe type of sickle cell disease.

Why is early detection of Sickle Cell Disease important?

Early diagnosis and treatment of sickle cell disease can help reduce the risk of developing sickle cell anemia and other complications associated with the condition.

What does an abnormal result mean?

This test is a screening tool to help identify sickle cell disease. If your results are abnormal you should share your results with a health care provider who can evaluate your symptoms and medical history, and diagnose sickle cell disease.

Can I use my FSA or HSA funds to purchase tests at questhealth.com?

You may be able to use your FSA or HSA funds to purchase lab tests at questhealth.com. Please review your FSA/HSA plan or check with a tax professional to confirm specific requirements for individual eligibility.

Our references

https://www.ncaa.org/sports/2016/7/27/sickle-cell-trait.aspx

Tests purchased on questhealth.com are only for individuals who intend to pay directly for testing and do not want to submit a claim for reimbursement under their health insurance.

Sickle Cell Trait Screen Test with Reflex