Get $100 off the AD-Detect Test for Alzheimer's Disease Risk through October 1st. View terms >
Stress and Nutrition Antioxidant Screen
Stress and Nutrition Antioxidant Screen
Measure your oxidative stress levels to help you understand how an imbalance in certain antioxidants can put you at risk for developing chronic health conditions such as cancer, heart disease, or other chronic conditions. Read moreTest details
Sample type:
Urine
Preparation:
You do not need to do anything special to prepare for the sample collection.
Fasting is not required for this test.
$99.00
+ $6.00 Physician Service Fee
What
This test measures the F2-isoprostane/creatinine ratio, which reflects oxidative stress in the body.
Who
Must be 18+ years of age to purchase.
How
Urine
Schedule an appointment, then visit one of the Quest Diagnostics Patient Service Centers
About the Test
Oxidation is an essential process that helps your body convert food into energy, eliminate toxins, and repair cells. Without oxidation, the body would be unable to function properly. However, excessive oxidation can also be damaging to the body. This is called oxidative stress. This imbalance can lead to cellular damage and various health conditions.
This test is useful for anyone who wants to evaluate their oxidative stress levels, including those with risk factors such as smoking, unbalanced diet, high cholesterol (hyperlipidemia), or a family history of cardiovascular disease.
An abnormal result may indicate an increased risk of developing certain health conditions such as cancer, heart disease, or diabetes. A healthcare provider may recommend dietary or lifestyle changes or further testing to rule out or confirm potential health risks or disorders
How Does it Work?
Take an in-person test at a Quest Diagnostics location.
Over 2000+ locations focus on your safety, confidentiality and convenience.
1. Purchase your test
Schedule your appointment after purchasing a test to minimize wait time.
2. Visit a location
Enter your zip code to find a Quest Diagnostics location closest to you.
3. Get results online
We will email you when your confidential results are available.
Take an in-person test at a Quest Diagnostics location.
Over 2000+ locations focus on your safety, confidentiality and convenience.
1. Purchase your test
Schedule your appointment after purchasing a test to minimize wait time.
2. Visit a location
Enter your zip code to find a Quest Diagnostics location closest to you.
3. Get results online
We will email you when your confidential results are available.
What to expect with Quest

Health insights, on your terms
Get lab work without having to wait and pay for an appointment with a doctor. Shop questhealth.com and choose from 75+ tests – the same quality tests that doctors use and trust, but no doctor visit required for purchase.

Easy to buy & simple to schedule
After your purchase, schedule an appointment at a nearby Quest Diagnostics location and have your specimen sample collected by a trained healthcare professional.

Fast online results, with support
Access test results from your phone as soon as they’re available, with the option to discuss your results with an independent physician at no extra cost.
FAQs
Your body experiences oxidative stress when your antioxidant levels are low. Antioxidants are molecules that fight free radicals in your body.
When reactive oxygen species (ROS), commonly known as free radicals, and antioxidant defenses are out of balance, your body experiences oxidative stress. This imbalance can contribute to developing certain health conditions. However, there may be some benefits from this imbalance. Although oxidative stress has more harmful than beneficial properties, some studies have shown that oxidative stress can help fight diseases like cancer.
Overproduction of free radicals can lead to oxidative damage to lipids, proteins, DNA, and RNA and may ultimately result in chronic health conditions, including hardening of the blood vessels (atherosclerosis), cancer, diabetes, rheumatoid arthritis, hypertension, cardiovascular disease, chronic inflammation, and neurodegenerative diseases such Parkinson disease and as Alzheimer’s.
Diet and lifestyle play a role in the development and management of chronic conditions. Prior to the onset of chronic diseases, it is advisable to determine whether lifestyle and nutritional changes are necessary and consult a medical professional for next steps.
Although it is difficult to eliminate free radicals and oxidative stress entirely, you can reduce the impact of oxidative stress on your body by:
- Eating more fruits and vegetables
- Reducing red meat consumption
- Exercising regularly
- Losing excess weight, weight management
- Quitting smoking
- Limiting alcohol intake
- Avoiding overeating
- Being aware of pesticides and other pollutants
- Wearing sunscreen
- Getting adequate sleep
Yes, a Stress and Nutrition Antioxidant Screen is also known as an IsoPF2, F2 Isoprostane, F2CR, F2ISO, or F2-IsoPs test.
Yes, psychological stress is associated with increased oxidant production and oxidative damage. Long-term exposure to psychological stressors may raise the likelihood of developing a variety of diseases.
Intense stress overstimulates the immune system, which disrupts the balance between inflammatory and anti-inflammatory responses. Chronic inflammation can harm cells and lead to the formation of free radicals. This can cause further damage to cells, resulting in a destructive cycle of cell death. While our bodies have mechanisms in place to repair this damage, if we are consistently stressed, these processes may become overburdened and unable to keep up. This can lead to an increase in oxidative stress and an increased risk of disease.
The F2-isoprostane/creatinine ratio is a way of measuring the levels of F2-isoprostanes in a urine sample. Creatinine levels help to normalize F2-isoprostane levels, so the 2 can be compared between different samples. This ratio is important because it can help to identify individuals who may be at risk for developing certain diseases, such as cardiovascular disease and Alzheimer's. The higher the ratio, the greater the level of F2-isoprostanes in the body, and greater possible risk for these diseases.
Plant-based foods are the best sources of antioxidants. Some of the best sources of antioxidants include fruits (blueberries, strawberries, raspberries), vegetables (carrots, kale, spinach), whole grains (corn, oats, black rice), and beans (black, pinto, kidney). Adding these foods to your diet is a great way to boost your antioxidant intake.