Home Shop Tests Hormone & Thyroid Health

Best Seller

Men's Hormone Test Panel — Expanded

$176.00 ~~$220.00~~ 20% off

+ $6.00 Physician Service Fee

HSA/FSA Accepted

20% Off

Hormone imbalances, including low testosterone, can contribute to symptoms such as low energy, reduced sex drive, and changes in physical and reproductive health. This expanded panel measures additional hormones—like estradiol and prolactin—to provide a more complete view of your hormone levels and support informed conversations with your healthcare provider. Read more

Quantity

Want more insights?

Expand your results by adding on these custom panels

Cortisol & DHEA-S (Adrenal Function) Test Panel — Morning Snapshot

Measure morning cortisol and DHEA-S levels that may affect adrenal function.

+ $79.20 20% off

~~$99.00~~

20% Off

0 additional tests selected

What

This panel measures levels of the following hormones and proteins/biomarkers in your blood, including testosterone (free, bioavailable, and total); sex hormone-binding globulin (SHBG); albumin; estradiol; and prolactin.

Who

Those who experience any symptoms mentioned above or are interested in checking hormone levels that impact their sexual development, function, and health. Must be 18 years of age to purchase.

How

Blood

Where

Find a location near you

Schedule an appointment, then visit one of the Quest Diagnostics Patient Service Centers.

This expanded men’s hormone panel measures free, bioavailable, and total testosterone, sex hormone-binding globulin (SHBG), albumin, estradiol, and prolactin levels in the blood. These hormones play important roles in building and maintaining muscle mass and bone density, energy levels, mood, and sexual health.

Testosterone levels can vary based on age, overall health, medications, sleep, and other lifestyle factors. Measuring testosterone along with related hormones and proteins can provide a more complete picture of hormone balance and support evaluation of conditions, such as hypogonadism or pituitary-related disorders, when interpreted by a healthcare provider. Understanding your hormone levels can help guide next steps and support conversations about your health.

No doctor’s visit needed. Buy this expanded men's hormone test, visit a nearby Quest location, and get fast results.

Sample type: Blood
Test type: In Person
Find Patient Service Centers

Preparation: Morning sample collection is preferred. Fasting (not eating or drinking anything except water) for 8-12 hours is required.

This test may be right for you if any the following are true:

You are experiencing symptoms of hormone imbalance disorders (listed below in the Signs & symptoms section)
You are interested in hormones that may play a role in reproductive health
You want to better understand your current hormone levels
You want to establish a baseline for tracking changes over time
You are a transgender male or female and want to evaluate your hormone levels

Hormone imbalances can only be diagnosed by a health care professional based on your symptoms and history. By getting tested, you and your healthcare provider can understand the cause of your symptoms and identify next steps.

This test panel measures hormone and protein/biomarker levels in your blood that are commonly evaluated by healthcare providers to diagnose hormone imbalance disorders, such as hypogonadism, hypopituitarism, and others.

Testosterone is an androgen steroid hormone and the principal male sex hormone. In men, it plays a key role in development of the male reproductive system that regulates sex drive and is essential for sperm production. Testosterone also promotes secondary sexual characteristics such as facial and chest hair, bone health, upper body muscle mass and strength, and regulates body fat distribution. It is primarily secreted from the testes.

Low levels of testosterone are associated with aging and common medical conditions including diabetes, high blood pressure, and obesity. Abnormal levels of testosterone in the blood may cause changes in health and physical appearance.

Free Testosterone: Testosterone that is active and unbound to a protein (like SHBG or albumin)
Bioavailable Testosterone: Sum of free testosterone and testosterone bound to albumin
Total Testosterone: Sum of all testosterone in the bloodstream

Sex hormone-binding globulin (SHBG) is a protein made by your liver that transports and controls the amount of hormones available for your body to use. High or low SHBG levels can be a sign that there are too many or too little hormones available for your body to use.

Albumin is also a protein in the blood that transports various metals, drugs, and metabolites throughout the body, including hormones. Like SHBG, it helps in determining the amount of free and bioavailable testosterone in the body.

A small amount of testosterone is converted into estradiol. This is the main form of estrogen in men. Estradiol is a steroid hormone that helps control erectile function, libido, and sperm production. As men age, they often make less testosterone, and so they produce less estradiol as well. Changes often attributed to testosterone deficiency might be partly or entirely due to the accompanying decline in estradiol. Elevated estradiol levels in males may result in breast tissue growth (gynecomastia), infertility, or erectile dysfunction.

Prolactin is a hormone produced in the pituitary gland and plays a role in regulating testosterone secretion, sperm production, and reproductive function. When a man has high levels of prolactin, a condition called hyperprolactinemia, it can interfere with the production of testosterone, which is necessary to produce sperm. This can result in a reduced sperm count or no sperm production at all, leading to infertility. It can also cause other symptoms, such as galactorrhea (production of breast milk in men) or reduced sex drive.

Hormone imbalances can affect the body in many ways. In men, low testosterone levels are more common than high levels. Some men can have abnormal testosterone levels for years without knowing.

Symptoms of low testosterone in men can include:

Reduced sex drive
Difficulty with erections
Decreased muscle mass
Reduced bone density
Breast tissue development
Hair loss
Difficulty sleeping
Difficulty with memory and concentration
Decrease in testicle size
Decrease in sperm production that can lead to fertility problems

Symptoms of high testosterone in men can include:

Elevated blood pressure
Heart or liver problems
Headaches
Changes in mood, including aggression
Increased body hair
Acne
Prostate enlargement
Decrease in sperm production that can lead to fertility problems
Insomnia

Purchaser: You must be 18 years of age or older to purchase a test on questhealth.com.

Patient: This test can be performed on patients between 18 and 100 years old.

Sample collection: This test requires sample collection at a Quest Diagnostics location or through Quest Mobile® where available, a convenient option for in-home sample collection*. Collection is not available in AZ or HI.

*Check your zip code here for service availability, not available in all locations. Quest Mobile is currently only available for individuals ages 18+.

Morning sample collection is preferred. Fasting (not eating or drinking anything except water) for 8-12 hours is required.

After you provide your specimen, it generally takes up to 5 business days to process and release your test results. However, processing times may vary. Your test results will be available in a clear and easy-to-read report. If you have or create a MyQuest® account, you may be able to review your new results there with your other Quest results. Independent healthcare providers are available to discuss questions or concerns you may have regarding your results.

Compare products

Test For	Men's Hormone Test Panel — Expanded	Men's Hormone Test Panel — Basic
Testosterone (Free, bioavailable, and total)
Sex hormone-binding globulin (SHBG)
Albumin
Estradiol
Prolactin
	$176.00 ~~$220.00~~	$121.60 ~~$152.00~~ Learn More

Men's Hormone Test Panel — Expanded	Men's Hormone Test Panel — Basic
Testosterone (Free, bioavailable, and total)
Sex hormone-binding globulin (SHBG)
Albumin
Estradiol
Prolactin
$176.00 ~~$220.00~~	$121.60 ~~$152.00~~ Learn More

How it works

questhealth.com offers 150+ consumer-initiated Quest Diagnostics lab tests to empower you to have more control over your health journey. Choose from a variety of test types that best suit your needs.

In-person
In-home sample collection

Buy a lab test

No doctor visit is required for purchase, but an independent healthcare provider is involved throughout the process.

Shop now

Register your test
& schedule an appointment

Book a visit to one of 2000+ Quest locations.

Visit Quest for sample collection

Complete your test sample collection during your scheduled appointment.

Get fast results

Access results online as soon as they’re available. You will be emailed when they are ready. Discuss your results with an independent healthcare provider at no extra cost. Treatment options may be available.

Buy a lab test
+ in-home sample collection

No doctor visit required for purchase. If in-home service is available in your area, purchase for an additional $79 fee.

Buy now

Register your test
& schedule an appointment

After you make a purchase, register your test and Quest Mobile will contact you to schedule an in-home sample collection appointment.

In-home sample collection

A Quest Mobile phlebotomist will collect your sample and deliver it to Quest Diagnostics.

Get fast results

Please note: Quest Mobile is currently only available for individuals ages 18+.

Testing for hormone imbalances is essential for identifying potential underlying conditions and determining appropriate treatment options.

When it comes to men’s health, testosterone often gets all the attention. But it’s just one part of a larger, connected system. Overlooked, yet critical: estradiol, prolactin, SHBG, and albumin are also key players. Read the article to learn more.

FAQs

What is hypogonadism?

Hypogonadism in men is a condition in which the body does not make enough testosterone.

Symptoms in men can include:

Decrease in sex drive
Difficulty getting or maintaining an erection
Decrease in muscle mass
Bone weakness
Breast tissue development
Hair loss
Difficulty with memory and concentration
Decrease in testicle size
Decrease in semen production causing fertility problems

Hypogonadism can occur if:

Your testes are not making enough testosterone
Your brain does not signal the testes to make enough testosterone
You are taking medication or are undergoing cancer treatment that changes the amount of testosterone that your body makes

Can lifestyle cause low testosterone?

Low testosterone levels can be caused by a variety of factors, including age, obesity, alcohol, smoking habits, and a sedentary lifestyle.

I am a trans male / trans female. Is this test right for me?

Yes, this test is NOT just for those who were assigned male at birth. This test can be taken by anyone who would like to assess their hormone levels but should ultimately be discussed with your healthcare provider if undergoing hormone therapy.

Why should I measure free and bioavailable testosterone?

Most testosterone in the bloodstream is bound to proteins such as SHBG and albumin. Only a small portion circulates as “free” testosterone. Measuring these values together can provide additional context beyond total testosterone alone.

Why is a morning sample recommended?

Testosterone levels naturally fluctuate throughout the day and are typically highest in the morning (between 7–10 AM). Collecting your sample earlier in the day helps provide the most consistent and clinically useful measurement.

What’s the difference between the Men’s Basic and Expanded Hormone Test Panels?

The Expanded panel (this test) includes estradiol and prolactin in addition to testosterone, SHBG, and albumin. Estradiol and prolactin are hormones that can influence testosterone levels and overall hormone balance. Measuring them alongside testosterone can provide additional context and help support more informed discussions with your healthcare provider. These additional markers provide a more comprehensive view of hormone balance compared to the Basic panel.

Can I use my FSA or HSA funds to purchase tests at questhealth.com?

You may be able to use your FSA or HSA funds to purchase lab tests at questhealth.com. Please review your FSA/HSA plan or check with a tax professional to confirm specific requirements for individual eligibility.

Are tests purchased from questhealth.com covered by my health insurance?

Tests purchased on questhealth.com are intended for individuals paying directly—we do not bill insurance, and purchases cannot be submitted for insurance reimbursement.

If your doctor ordered a lab test for you and you are looking to book an appointment for sample collection, you can schedule an appointment here https://appointment.questdiagnostics.com/as-home.

For other questions related to a lab test your doctor ordered for you, including billing and results, you can visit the main Quest Diagnostics site here https://www.questdiagnostics.com.

Our references

Human Reproduction Update, Volume 29, Issue 2, March-April 2023, Pages 157–176, https://doi.org/10.1093/humupd/dmac035

Quest Diagnostics. Testosterone, Free, Bioavailable and Total, MS. Accessed March 24, 2026. https://testdirectory.questdiagnostics.com/test/test-detail/14966/testosterone-free-bioavailable-and-total-ms?p=r&q=14966&cc=PHP

Quest Diagnostics. Estradiol. Accessed March 24, 2026. https://testdirectory.questdiagnostics.com/test/test-detail/4021/estradiol?q=estradiol&cc=SKB

Quest Diagnostics. Prolactin. Accessed March 24, 2026. https://testdirectory.questdiagnostics.com/test/test-detail/746/prolactin?p=r&q=prolactin&cc=PHP

Cleveland Clinic. Testosterone Test. Accessed March 24, 2026. https://my.clevelandclinic.org/health/diagnostics/24215-testosterone-test

Cleveland Clinic. Androgens. Accessed March 24, 2026. https://my.clevelandclinic.org/health/articles/22002-androgens

National Institutes of Health. Understanding How Testosterone Affects Men. Accessed March 24, 2026. https://stagetestdomain3.nih.gov/news-events/nih-research-matters/understanding-how-testosterone-affects-men

Healthline. What causes high estrogen levels? Accessed March 24, 2026. https://www.healthline.com/health/high-estrogen#causes

MedlinePlus. SHBG Blood Test. Accessed March 24, 2026. https://medlineplus.gov/lab-tests/shbg-blood-test/

American Society for Reproductive Medicine. Hyperprolactinemia (High Prolactin Levels). Accessed March 24, 2026. https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/hyperprolactinemia-high-prolactin-levels/

NIH National Library of Medicine National Center for Biotechnology Information. Testosterone meets albumin – the molecular mechanism of sex hormone transport by serum albumins. Accessed March 24, 2026. https://pmc.ncbi.nlm.nih.gov/articles/PMC6371759/

Tests purchased on questhealth.com are only for individuals who intend to pay directly for testing and do not want to submit a claim for reimbursement under their health insurance.