Sickle Cell Trait Screen Test with Reflex

Sickle Cell Trait Screen Test with Reflex

Detect abnormal types of hemoglobin in the blood to help diagnose disorders such as sickle cell anemia, a genetic blood disorder caused by a gene mutation. If the initial screen is abnormal, additional tests are performed to determine which type of abnormal hemoglobin is present. Read more
Test details

Sample type:
You do not need to do anything special to prepare for the sample collection. Fasting is not required for this test.
Test type: In Person
Find Patient Service Centers
+ $6.00 Physician Service Fee
Do you have any of the following severe symptoms associated with Sickle Cell Anemia?
Unfortunately this test is not right for you based on your responses.

What Icon
A screen for the presence of abnormal types of hemoglobin, and if positive, a reflex test for the presence of sickle hemoglobin proteins (hemoglobin S and Hemoglobin C-Harlem).
Who Icon
Must be 18+ years of age to purchase.
How Icon
Schedule an appointment, then visit a Quest Diagnostics patient service center location.
About the Test

This screens for Hemoglobin-S and Hemoglobin C Harlem, which are abnormal types of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen throughout the body. These tests are used by physicians to help diagnose sickle cell anemia, a genetic blood disorder caused by a gene mutation. Red blood cells are usually round and flexible and can move easily through blood vessels. In sickle cell anemia, some of the red blood cells are c-shaped like sickles or crescents and can become rigid and difficult to pass through the bloodstream. This can slow down or block blood flow and decrease oxygen levels. Hemoglobin-S cells have a shorter lifespan than regular hemoglobin cells, which can lead to a severe shortage of healthy red blood cells (anemia).

The sickle cell trait screen can indicate a positive or negative presence of Hemoglobin-S and/or Hemoglobin-C Harlem. If your sickle cell screen is positive, a hemoglobinopathy evaluation will be conducted at no additional charge to help determine sickle cell disease or trait. The Hemoglobinopathy evaluation will provide results for Hemoglobin A, Hemoglobin A2, and any hemoglobin variants.

Take an in-person test at a Quest Diagnostics location.
Over 2000+ locations focus on your safety, confidentiality and convenience.
1. Purchase your test
Schedule your appointment after purchasing a test to minimize wait time.
2. Visit a location
Enter your zip code to find a Quest Diagnostics location closest to you.
3. Get results online
We will email you when your confidential results are available. 

What to expect with Quest

Health insights, on your terms

Get lab work without having to wait and pay for an appointment with a doctor. Shop and choose from 75+ tests – the same quality tests that doctors use and trust, but no doctor visit required for purchase.

Easy to buy & simple to schedule

After your purchase, schedule an appointment at a nearby Quest Diagnostics location and have your specimen sample collected by a trained healthcare professional.

Fast online results, with support

Access test results from your phone as soon as they’re available, with the option to discuss your results with an independent physician at no extra cost.