Sickle Cell Anemia Test with Reflex
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Orders not permitted in: AK, HI, AZ
• Blood (venipuncture - a needle is used to draw blood from a vein)
The Sickle Cell Anemia Test with Reflex includes a sickle cell screen for Hemoglobin-S and Hemoglobin C Harlem, which are abnormal types of hemoglobin. Hemoglobin is the protein in red blood cells that carries oxygen throughout the body. Red blood cells are usually round and flexible and can move easily through blood vessels. In sickle cell anemia, some of the red blood cells are c-shaped like sickles or crescents and can become rigid and difficult to pass through the bloodstream. This can slow down or block blood flow and decrease oxygen levels. Hemoglobin-S cells have a shorter lifespan than regular hemoglobin cells, which can lead to a severe shortage of healthy red blood cells (anemia).
The sickle cell screen can indicate a positive or negative presence of Hemoglobin-S and/or Hemoglobin-C Harlem. If your sickle cell screen is positive, a hemoglobinopathy evaluation will be conducted at no additional charge to help determine sickle cell disease or trait. The Hemoglobinopathy evaluation will provide results for Hemoglobin A, Hemoglobin A2, and any hemoglobin variants.
The benefits of testing
You can get the information you need to support a healthy life - for yourself.
Take control of your health
Conveniently shop and pay online for lab tests without a doctor's visit. An independent physician will review your request and if appropriate, confirm your order and offer oversight.
Schedule and manage your appointments
Conveniently schedule your appointment online at one of our Quest Diagnostics locations. Certain tests may also offer self-testing home delivery.
Get your results online
View your results through your secure account online. And it's easy to share the result with your doctor.
People with sickle cell disease have the hemoglobin S gene mutation on both of their beta globin genes, whereas people with sickle cell trait (Hgb A/S) have the mutation on only one beta globin gene.
People with sickle cell trait are carriers of the mutation and are generally asymptomatic, however, there are rare cases where sickle cell formation can lead to pain crises in some people from certain conditions including high altitudes, dehydration, increased air pressure. Athletes and those who participate in activities like flying or scuba diving may be more vulnerable to complications of sickle cell trait.