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Comprehensive Thyroid Test Panel

$119.20 ~~$149.00~~ 20% off

+ $6.00 Physician Service Fee

HSA/FSA Accepted

20% off

This panel is designed to help provide a comprehensive overview of thyroid function and health. It measures 3 hormones (TSH, free T3, & free T4) and 2 antibodies to TPO & Tg to help assess how well your thyroid is working and whether autoimmune activity may be affecting the thyroid gland. Read more

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This comprehensive thyroid panel measures 3 key hormones — TSH, free T3, and free T4 — to evaluate how well the thyroid is producing and regulating hormones. It also measures 2 autoimmune antibodies to thyroid peroxidase (TPO) and thyroglobulin (Tg) — to help assess whether immune activity may be contributing to potential thyroid dysfunction. Together, these 5 markers may help provide a comprehensive view of thyroid function and thyroid health beyond the baseline TSH test typically included in annual health checks.

Thyroid testing is often used when evaluating symptoms such as fatigue, weight changes, hair thinning, temperature sensitivity, mood changes, or changes in heart rate and is a core part of overall health. Testing for antibodies in addition to hormone levels can help identify whether thyroid changes may be related to autoimmune conditions, which are a common cause of thyroid dysfunction.

This panel may help individuals and their providers investigate symptoms of thyroid dysfunction, monitor known thyroid conditions or response to thyroid treatment, and may also be recommended for those with a personal or family history of autoimmune conditions that tend to cluster with thyroid dysfunction.

No doctor’s visit needed. Buy this full thyroid panel online, visit a nearby Quest location, and get fast results.

Sample type: Blood
Test type: In Person
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Preparation: Certain supplements and medications can interfere with your test results. If you are concerned about any of your supplements or medications impacting your results, talk to your healthcare provider before your sample is collected to see if you should stop taking them and for how long.

This test may be right for you if any the following are true:

You are experiencing symptoms of thyroid dysfunction including fatigue, weight changes, hair thinning, temperature sensitivity, mood changes, or heart rate changes
You have a known thyroid condition and want a more comprehensive view of your thyroid health and potential autoimmune activity
You are currently on thyroid medication and want to monitor your thyroid levels and health more comprehensively
You want a broader picture of your thyroid function and overall health
You have a personal or family history of thyroid or other autoimmune conditions
You are postpartum, perimenopausal, or planning a pregnancy, and want to assess your thyroid health
You want to establish a broader baseline for thyroid function changes over time

This test measures thyroid-stimulating hormone (TSH), free T4, free T3, thyroid peroxidase (TPO) antibodies, and thyroglobulin (Tg) antibodies.

About the thyroid

The thyroid is a butterfly-shaped gland in the front of the neck that helps regulate how your body uses energy. It plays a role in many essential processes, including metabolism, heart rate, body temperature, and nervous system function. Thyroid activity is regulated by the pituitary gland, which produces thyroid-stimulating hormone (TSH). TSH signals the thyroid to produce thyroid hormones—primarily T4, which the body converts as needed to T3. When this system is out of balance, it can lead to thyroid disorders that affect many parts of the body. While untreated thyroid disease can increase the risk of complications, most thyroid conditions can be effectively managed with medication and regular monitoring. As with many other organs, thyroid health can be affected by various autoimmune conditions, which can be assessed by testing for antibodies to TPO and Tg.

TSH helps control how much thyroid hormone your body produces. High TSH levels may indicate an underactive thyroid (hypothyroidism) Low TSH levels may indicate an overactive thyroid (hyperthyroidism) TSH is often the first marker used to assess thyroid function and is commonly tracked over time in people with known thyroid conditions. Thyroid-stimulating hormone (TSH) levels in the blood are measured to evaluate thyroid function, which is critical for regulating weight, energy, body temperature, mood, and overall health. If your TSH levels are abnormally high or low, this may indicate that your thyroid is either underactive (hypothyroidism) or overactive (hyperthyroidism). If test results identify abnormal TSH levels, free thyroxine (T4) blood levels will be evaluated using your submitted sample to provide information needed to accurately diagnose hypothyroidism.

T4 (thyroxine) is a thyroid hormone produced by the thyroid gland and is the main form of thyroid hormone in the blood. Free T4 is not bound to proteins and can enter bodily tissue. Measuring free T4 helps to diagnose hypo- and hyperthyroidism and monitor treatment.

T3 (triiodothyronine) is a thyroid hormone produced by the thyroid gland. Free T3 is not bound to proteins and can enter bodily tissue. Measuring free T3 helps to diagnose and monitor treatment for hyperthyroidism.

Thyroid peroxidase (TPO) is an enzyme involved in the production of thyroid hormones. TPO antibodies are produced when the immune system mistakenly targets the thyroid gland. Measuring TPO antibodies helps:

Identify autoimmune-related thyroid conditions
Support evaluation of conditions such as Hashimoto’s disease and certain forms of thyroiditis
Provide additional context when thyroid hormone levels are abnormal or borderline

Elevated TPO antibodies may be present before changes in TSH or T4 are detected and can help predict the risk of worsened thyroid dysfunction. TPO antibody testing is commonly used to support diagnosis and inform long-term monitoring, particularly in individuals with known or suspected autoimmune thyroid disease.

Thyroglobulin (Tg) is a protein made by thyroid cells that helps make T3 and T4. Tg antibodies are made when the body’s immune system mistakenly attacks this protein, which can indicate autoimmune activity that is affecting the thyroid. Measuring Tg antibodies alongside TPO antibodies can be useful to your healthcare provider in the management of a variety of thyroid disorders including Hashimoto's thyroiditis, Graves' disease, and certain types of goiter.

Symptoms of thyroid disorders can be mild, moderate, or severe and often resemble other medical conditions. You may consider this test if you're experiencing any of the following symptoms:

Hypothyroidism (underactive thyroid) symptoms can include:

Weight gain
Fatigue
Increased sensitivity to cold
Thinning hair
Enlarged thyroid gland (goiter)
Muscle aches and pains
Joint pain and stiffness
Elevated cholesterol levels
Constipation
Depression
Problems with memory
Slower than normal heart rate
Dry skin
Muscle weakness
Facial puffiness
Hoarseness

Hyperthyroidism (overactive thyroid) symptoms can include:

Increased appetite
Irregular heartbeat
Palpitations—a fluttering or pounding heartbeat
Unintentional weight loss
More frequent bowel movements
Anxiety or nervousness
Sweating

Purchaser: You must be 18 years of age or older to purchase a test on questhealth.com.

Patient: This test can be performed on patients between 18 and 100 years old.

Sample collection: This test requires sample collection at a Quest Diagnostics location or through Quest Mobile® where available, a convenient location for in-home sample collection*. Collection is not available in AZ, HI, or PR.

*Check your zip code here for service availability, testing may not be available in all locations.

No special preparation is required. Certain supplements and medications can interfere with your test results. If you are concerned about any of your supplements or medications impacting your results, talk to your healthcare provider before your sample is collected to see if you should stop taking them and for how long.

After you provide your specimen, it generally takes a few business days to process and release your test results. However, processing times may vary. Your test results will be available in a clear and easy-to-read report. If you have or create a MyQuest® account, you may be able to review your new results there with your other Quest results. If your results differ from expected ranges, you may receive an alert call from an independent healthcare coordinator. Independent healthcare providers are available to discuss questions or concerns you may have regarding your results. This healthcare provider may be able to prescribe treatment, if appropriate.

Included with your purchase, you have the ability to discuss your results with an independent healthcare provider who may be able to prescribe hypothyroidism specific treatment, depending on your results.

Compare products

Test For	Comprehensive Thyroid Test Panel	Thyroid Disorder Monitoring — Initial	Thyroid Disorder Monitoring — Ongoing	Elite Health Profile
Thyroid-stimulating hormone (TSH)
Free T4
Free T3
Thyroid peroxidase (TPO) antibodies
Thyroglobulin antibodies (TgAb)
Complete blood count (CBC)
Comprehensive metabolic panel (CMP)
Cholesterol panel
Glucose
Urinalysis
hs-CRP
Hemoglobin A1c (HbA1c)
Vitamin D
Electrolytes: calcium, sodium, potassium, chloride
Testosterone
Apolipoprotein B
Insulin, Free
Ferritin
Vitamin B9 (Folate)
Vitamin B12 (Cobalamin)
Physical measurements (Biometrics)
Health risk assessment
Health Quotient Score
	$119.20 ~~$149.00~~	$97.75 ~~$115.00~~ Learn More	$61.20 ~~$72.00~~ Learn More	$359.20 ~~$449.00~~ Learn More

Comprehensive Thyroid Test Panel	Thyroid Disorder Monitoring — Initial	Thyroid Disorder Monitoring — Ongoing	Elite Health Profile
Thyroid-stimulating hormone (TSH)
Free T4
Free T3
Thyroid peroxidase (TPO) antibodies
Thyroglobulin antibodies (TgAb)
Complete blood count (CBC)
Comprehensive metabolic panel (CMP)
Cholesterol panel
Glucose
Urinalysis
hs-CRP
Hemoglobin A1c (HbA1c)
Vitamin D
Electrolytes: calcium, sodium, potassium, chloride
Testosterone
Apolipoprotein B
Insulin, Free
Ferritin
Vitamin B9 (Folate)
Vitamin B12 (Cobalamin)
Physical measurements (Biometrics)
Health risk assessment
Health Quotient Score
$119.20 ~~$149.00~~	$97.75 ~~$115.00~~ Learn More	$61.20 ~~$72.00~~ Learn More	$359.20 ~~$449.00~~ Learn More

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questhealth.com offers 150+ consumer-initiated Quest Diagnostics lab tests to empower you to have more control over your health journey. Choose from a variety of test types that best suit your needs.

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Access results online as soon as they’re available. You will be emailed when they are ready. Discuss your results with an independent healthcare provider at no extra cost. Treatment options may be available.

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No doctor visit required for purchase. If in-home service is available in your area, purchase for an additional $79 fee.

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After you make a purchase, register your test and Quest Mobile will contact you to schedule an in-home sample collection appointment.

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A Quest Mobile phlebotomist will collect your sample and deliver it to Quest Diagnostics.

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Please note: Quest Mobile is currently only available for individuals ages 18+.

Hashimoto’s disease is a chronic autoimmune disease affecting millions of Americans, yet many live with it for years without knowing. Understanding what's happening, how it develops, and what your symptoms may mean.

Thyroid disorders can affect men and women of all ages. Getting tested is important, especially for those with a family history, as undiagnosed thyroid disease can contribute to infertility, sexual dysfunction, osteoporosis and heart disease.

FAQs

Which thyroid disorder is most common, hypothyroidism or hyperthyroidism?

Hypothyroidism (underactive thyroid) is significantly more common than hyperthyroidism (overactive thyroid).

How common is hypothyroidism?

About 5 percent of Americans who are 12 years old or older have hypothyroidism. Many people who have hypothyroidism are unaware.¹ It is estimated that around 12% of the US population will develop a thyroid condition in their lifetimes.²

What’s the difference between this panel and a “basic thyroid test”?

A basic thyroid test may measure TSH alone, which is a useful first indicator of thyroid function. This comprehensive panel additionally measures free T3 and free T4 to provide a fuller picture of how your thyroid is producing and regulating hormones. It also measures TPO and Tg antibodies to assess whether autoimmune activity may be contributing to thyroid dysfunction. This makes it particularly useful for those who want a more complete evaluation or whose symptoms or history suggest autoimmune involvement.

What do TPO antibodies and Tg antibodies tell me that hormone tests alone don’t?

Thyroid hormone levels show how well your thyroid is currently functioning, but they don’t explain why dysfunction may be occurring. TPO antibodies and Tg antibodies can help identify whether the immune system is mistakenly targeting the thyroid gland — a common underlying cause of thyroid dysfunction. TPO antibodies are the primary marker of autoimmune thyroid disease, while Tg antibodies can add additional information. Elevated TPO antibodies in particular may also be present before hormone levels become abnormal, making them a useful early indicator for those at higher risk of thyroid disease.

How often should I have my thyroid function checked?

Currently, there is no evidence to support routine screening of your thyroid function. You may consider checking your thyroid function if you are having symptoms of a thyroid disorder or if you are at high risk for developing a thyroid disease. If you have been diagnosed with a thyroid disorder, you may have your thyroid function checked more frequently. Consult with your healthcare provider to determine a longer-term care plan.

Are there risk factors to be aware of for developing thyroid disease?

Even if you don’t have symptoms, you may consider testing if you have the following risk factors:

Family history of thyroid disease
Women, particularly those in hormone transition (eg, postpartum, perimenopause, menopause, post menopause, etc.)
People over age 50
Have an autoimmune disease such as type 1 diabetes
History of thyroid surgery
Radiation treatment for a past thyroid condition
Recent pregnancy or planning for a future pregnancy
Taking medication high in iodine

If I have a thyroid condition, how do I obtain treatment for it?

Initial testing for the evaluation of thyroid function should include TSH with reflex to serum T4 when TSH is abnormal. If treatment is started, recommended testing includes TSH and free T4 to be measured 6 weeks after initiation of treatment or if the dose is changed. Once steady state is achieved, annual monitoring of TSH is recommended or as needed if a patient develops new or worsening symptoms. If treatment is not started, but retesting or monitoring is warranted, it is recommended to test TSH and/or T4.

Testing TPO antibodies is recommended for subclinical hypothyroidism, painless (silent) thyroiditis, Hashimoto disease, or postpartum thyroiditis, to predict the likelihood of progression to permanent overt hypothyroidism. TPO antibody can also be measured in the presence of a goiter in patients with normal TSH. Thyroid Disorder Monitoring — Initial panel does test for TPO. The Thyroid Disorder Monitoring — Ongoing panel does not test for TPO.

If thyroid (TSH) is abnormal, T4 is also performed on the sample you have already provided. Included with your purchase, you have the ability to discuss your results with an independent healthcare provider who may be able to prescribe hypothyroidism specific treatment depending on your results.

Are women more likely to develop thyroid conditions?

Yes. Thyroid conditions are significantly more common in women than men. Women are also more likely to experience thyroid changes during periods of hormonal transition, including pregnancy, postpartum, perimenopause, menopause, and post menopause, when thyroid dysfunction can be harder to identify because symptoms often overlap with those of hormonal changes. That said, thyroid conditions still occur in men and may be overlooked due to the higher prevalence in women.

Can perimenopause, menopause, post menopause, or postpartum changes affect my thyroid?

Yes. Thyroid dysfunction is more common in the postpartum period and during the perimenopause, menopause, and post menopausal years. Symptoms of thyroid dysfunction such as fatigue, weight changes, mood changes, and temperature sensitivity can closely mirror those of hormonal transition, making testing a useful way to help distinguish between the two. If you are experiencing these symptoms during either life stage, discussing thyroid testing with your healthcare provider is worth considering.

Can thyroid dysfunction affect fertility or pregnancy?

Yes. Thyroid hormones play an important role in reproductive health and fetal development. Both hypothyroidism and hyperthyroidism can affect menstrual regularity and fertility, and unmanaged thyroid dysfunction during pregnancy is associated with complications for both mother and baby. For this reason, thyroid function testing is often recommended for those who are planning a pregnancy or experiencing fertility challenges.

I am already on thyroid medication — is this panel still useful for me?

Yes. If you are currently on thyroid medication, this panel can provide a more comprehensive view of how well your treatment is working. Measuring free T3 and free T4 alongside TSH can help assess whether hormone levels are well controlled, and antibody testing can provide additional context on underlying autoimmune activity. You should share your results with your healthcare provider to support any adjustments to your treatment plan.

If my results are abnormal, what are my next steps?

If your results fall outside the expected range, you may receive an alert call from an independent healthcare coordinator. Independent healthcare providers are available to discuss your results and answer questions. Depending on your results, an independent healthcare provider may also be able to discuss treatment options for hypothyroidism. As with all lab results, findings should be considered alongside your symptoms and health history.

I’ve heard there’s a connection between other autoimmune conditions and thyroid disease. Is that true?

Yes. Autoimmune thyroid conditions tend to cluster with other autoimmune diseases — meaning people with conditions such as type 1 diabetes, rheumatoid arthritis, lupus, or celiac disease are at higher risk of developing thyroid dysfunction. Autoimmune thyroid conditions occur when the immune system mistakenly targets the thyroid gland, causing inflammation that can affect its ability to produce hormones. The two most common autoimmune thyroid conditions are Hashimoto’s thyroiditis, which is the leading cause of hypothyroidism, and Graves’ disease, which is the most common cause of hyperthyroidism. Measuring TPO antibodies and Tg antibodies, as included in this panel, can help identify whether autoimmune activity may be contributing to thyroid dysfunction, even before symptoms are present.

Can I use my FSA or HSA funds to purchase tests on questhealth.com?

You may be able to use your FSA or HSA funds to purchase lab tests at questhealth.com. Please review your FSA/HSA plan or check with a tax professional to confirm specific requirements for individual eligibility.

Are tests purchased from questhealth.com covered by my health insurance?

Tests purchased on questhealth.com are intended for individuals paying directly—we do not bill insurance, and purchases cannot be submitted for insurance reimbursement.

If your doctor ordered a lab test for you and you are looking to book an appointment for sample collection, you can schedule an appointment here https://appointment.questdiagnostics.com/as-home.

For other questions related to a lab test your doctor ordered for you, including billing and results, you can visit the main Quest Diagnostics site here https://www.questdiagnostics.com.

Our references

Patil N, Rehman A, Anastasopoulou C, et al. Hypothyroidism. [Updated 2024 Feb 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519536/
American Thyroid Association. General Information/Press Room. Accessed April 15, 2026. https://www.thyroid.org/media-main/press-room/
MedlinePlus. Thyroid Antibodies. Accessed March 10, 2026. https://medlineplus.gov/lab-tests/thyroid-antibodies/
Cleveland Clinic. Thyroid Antibodies. Accessed March 10, 2026. https://my.clevelandclinic.org/health/diagnostics/thyroid-antibodies
Cleveland Clinic. Thyroid Hormone. Accessed March 10, 2026. https://my.clevelandclinic.org/health/articles/22391-thyroid-hormone
MedlinePlus. Thyroxine (T4) Test. Accessed March 10, 2026. https://medlineplus.gov/lab-tests/thyroxine-t4-test/
MedlinePlus. Triiodothyronine (T3) Tests. Accessed March 10, 2026. https://medlineplus.gov/lab-tests/triiodothyronine-t3-tests/
American Thyroid Association. Thyroid Function Tests. Accessed March 10, 2026. https://www.thyroid.org/thyroid-function-tests/
Kaur J, Jialal I. Hashimoto Thyroiditis. [Updated 2026 Feb 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459262/

Tests purchased on questhealth.com are only for individuals who intend to pay directly for testing and do not want to submit a claim for reimbursement under their health insurance.