AD-Detect Test for Alzheimer’s Disease RiskExclusively available at Quest. This screening test provides an amyloid ratio, which is a risk factor of Alzheimer’s disease. This ratio is based on two biomarkers that have been reported as helping to detect early signs associated with the risk of developing Alzheimer’s disease. This can potentially help you and your doctor design interventions and a management plan that is most beneficial to you. Read more
Alzheimer’s disease (AD) is a progressive brain-related disorder that affects memory and understanding and can progress to complete mental and physical impairment. This Alzheimer’s test measures A-beta 42 and A-beta 40 biomarkers and provides the A-beta 42/40 blood levels ratio. This ratio between these two molecular biomarkers may help to detect the risk of Alzheimer’s disease before severe mental decline.
For most people with Alzheimer’s disease — those who have the late-onset variety — symptoms first appear when someone is in their mid-60s or later. When the disease develops before the age of 65, it’s considered early-onset Alzheimer’s, which can begin as early as a person’s 30s, although this is rare.
While there is no cure for AD, there are treatments that can help slow its progression when detected early enough. Additionally, there are ongoing clinical trials where new therapies are continuously being developed and tested. Early detection can help encourage the necessary discussions with your doctor so you can minimize further risk through lifestyle modification and have discussions of treatment should they become available.
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The following risk-factors are associated with a higher likelihood of developing Alzheimer’s disease:
- experiencing memory loss or early cognitive impairment or decline(trouble remembering, concentrating, making decisions, etc.)
- having a family history of Alzheimer’s disease
- had past diagnosed brain trauma or head injury
- excessive alcohol consumption
- Alzheimer’s Association. More Women Get Alzheimer’s Than Men. Why? Accessed Aug 8, 2023. https://www.alz.org/news/2020/more-women-get-alzheimer-s-than-men-why
- Centers for Disease Control and Prevention. Alzheimer’s Disease and Related Dementias. Accessed July 3, 2023.https://www.cdc.gov/aging/aginginfo/alzheimers.htm
- National Institute on Aging. What Are the Signs on Alzheimer’s Disease? Accessed July 3, 2023. https://www.nia.nih.gov/health/what-are-signs-alzheimers-disease
- Quest Diagnostics. Quest AD-Detect™, Beta-Amyloid 42/40 Ratio, Plasma. Accessed April 20, 2023. https://testdirectory.questdiagnostics.com/test/test-detail/11786/quest-ad-detect-beta-amyloid-4240-ratio-plasma?p=r&q=11786&cc=PHP
- Alzheimer’s Association. What is Alzheimer’s Disease? Accessed 21 April, 2023. https://www.alz.org/alzheimers-dementia/what-is-alzheimers
- NHS inform. Alzheimer's disease. Accessed April 21, 2023. https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/alzheimers-disease
- Acta Pharmacologica Sinica. Amyloid beta: structure, biology and structure-based therapeutic development. Accessed April 22, 2023. https://www.nature.com/articles/aps201728
- Penn Medicine. The 7 Stages of Alzheimer's Disease. Accessed April 22, 2023. https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2019/november/stages-of-alzheimers
- Alzheimer’s Association. Causes and Risk Factors for Alzheimer's Disease. Accessed April 22, 2023. https://www.alz.org/alzheimers-dementia/what-is-alzheimers/causes-and-risk-factors
- SVAR Wieslab. Beta amyloid ratio 42/40. Accessed April 22, 2023. https://www.svarlifescience.com/services/wieslab-diagnostic-services/997-l-beta-amyloid-ratio-42-40